gRNAde

Geometric Deep Learning for 3D RNA Inverse Design (ICLR 2025 Spotlight): a multi-state GNN with autoregressive decoding for structure-conditioned RNA design. It matched human experts on blinded Eterna (95% vs 70% for prior automated methods), has ~309 GitHub stars, and spawned RNA-FrameFlow. Cambridge-led (Joshi, Liò senior).