AlphaFold 2

Solved protein structure prediction at atomic accuracy. Won CASP14 with a median GDT score of 92.4 (next best: 73). Predicted structures for 200M+ proteins (essentially all known proteins), made freely available via the AlphaFold Protein Structure Database.

AlphaFold 2 is arguably the greatest scientific achievement of deep learning. Named Nature's "Method of the Year 2021." Won the 2024 Nobel Prize in Chemistry for Demis Hassabis and John Jumper. ~43,000 citations. By Jumper, Evans et al. (DeepMind). Open-source code and weights.