AlphaFold 3

Diffusion-based architecture predicting joint structures of proteins with DNA, RNA, small molecules, and ions. 50%+ improvement over existing methods for protein-molecule interactions. Extends AlphaFold from protein-only to the full biomolecular landscape.

Code and weights released for academic use (November 2024, publicly February 2025). Nature 2024. By Abramson et al. (DeepMind / Isomorphic Labs).